What is Low CG Syndrome?
The CG stands for cysteine glutamine. Low C-G syndrome is low cysteine glutamine syndrome.
abnormally low plasma cysteine levels Low glutamine levels low glutathione (GSH) levels low natural killer(NK) cell action skeletal muscle wasting muscle fatigue increased rates of urea production
Skeletal muscle wasting or cachexia is a comorbidity or condition that is simultaneously present with numerous other diseases. Especially those listed just below.
If you see a common factor, then there is a powerful clue to find a treatment for these diseases.
These symptoms occur in those afflicted with...
cancer major surgeries sepsis Crohn’s disease ulcerative colitis chronic fatigue syndrome HIV infection over-trained athletes elderly fall victims end stages of many diseases
Note: cachexia is one of the diagnosis's making a patient eligible for hospice.
Because these symptoms appear in many diseases of different etiological origin, it is suspected that there is a causal relationship.
Low levels of natural killer cells and decreased activity in most cases is not life threatening. The exception is HIV infection.
In HIV, there is a balance between the immune system and the viral load. Disrupt the stability of the two and the disease can rapidly progress. The evidence of this can be seen in the decrease CD4+T cells. At the same time there is a decrease in the plasma cysteine level in these patients.
In 2008, a study at McGill University Hospital in Montreal Canada it was reported that cysteine and glutathione play an important role in the protection from skeletal muscle wasting.
The evidence suggested that cysteine levels are regulated by normal breaking down of skeletal muscle protein. The cysteine level itself seems to be a regulator of the nitrogen balance and the cell mass.
Nitrogen is part of DNA & RNA (nucleic acids). Nitrogen is essential for life. Nitrogen becomes Nitric Oxide. Nitric Oxide is an essential messenger for relaxing the muscles. However, once used, it leaves a byproduct.
When this byproduct is combined with the bodies byproduct of oxygen use (reactive oxygen species) the two are what is known as oxidants and cause damage to our cells. This damage results in the cachexia or muscle wasting.
When the breakdown (cachexia or muscle wasting) is occurring, the cysteine controlled regulation has been compromised. Conditions where this would or could happen include old age.
The study found that cysteine supplementation was a useful therapy. In the case of HIV infection, it even helped the other drugs (such as antiviral therapy) to work better.
* Based partly on the concise Encyclopedia of Chronic Fatigue Syndrome.
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