NAC Contraindications: A Comprehensive Review

With so many benefits, what are the NAC contraindications or the reasons you should not take if...? Here are NAC cautions or NAC restrictions.

N-acetylcysteine, also known as NAC, acetylcysteine, and mercapturic acid is a non-essential amino acid used in treating asthma, bronchitis, mercury poisoning, aging spots and has been studied in treating and resulting in beneficial results in over 60 other diseases or conditions. With all of the benefits, there are some important NAC contraindications.

You Should Not Take NAC If...

There are actually several contraindications or reasons you should not take if.....

If you choose to take any supplement on your own...and especially NAC, there are a few things you need to be aware of.

Do Not Use NAC if

  • you have an organ transplant
  • you have a stomach ulcer
  • Before Using NAC, Consult Your Doctor if you are...

  • using any medicine or if you are allergic to any medicine including supplements.
  • pregnant or plan to become pregnant while using this medicine
  • breast feeding
  • suffering with asthma
  • suffering with liver disease
  • suffering with asthma
  • managing high blood pressure
  • managing heart or blood vessel disease
  • Drug Interactions NAC Contraindications

    You should speak to your doctor or pharmacist before taking any N-acetylcysteine products if you are or will be taking any drugs but especially any of the following....

  • Activated charcoal
  • Ampicillin
  • Carbamazepine (Tegretol®)
  • Cephaloridine (Loridine(®)
  • Cloxacillin (Cloxapen®)
  • Methicillin (Staphcillin®)
  • Nitroglycerin (Nitrostat ®, Nitro-Dur ®, Nitro-Bid ®)
  • Oxacillin
  • Penicillin G
  • Quinacillin
  • Any Chemo Therapy
  • Radiation Treatments
  • Gentamicin
  • Warnings

    Large doses of N-acetylcysteine can be dangerous to nerve cells. Many websites erroneously indicate that NAC is safe even in large doses. In one test of healthy men, when given a large dose of NAC, severe health problems arose.

    It is also known to result in nerve damage when used in large doses.

    It should not be used if you have a stomach ulcer.

    It may cause kidney stones. It should be supplemented with vitamin C to help prevent stones.

    It should not be used if you have an organ transplant.

    Potential Side Effects:

    Immediately stop use and inform your doctor if you have...An allergic reaction such as itching or hives, swelling in the face or hands. If you have swelling in your mouth, throat, chest tightness or trouble breathing, it should also be discontinued and if necessary, emergency medical care.

    Other Side Effects:

    Rarely NAC may cause other side effects. Inform your doctor if you have side effects that you think are caused by NAC. These would include but are not limited to....

  • Fever or chills
  • Nausea (upset stomach)
  • Vomiting (throwing up)
  • Diarrhea
  • Cough, nose congestion, runny nose
  • Storage

    It is important to keep NAC away from children.

    Keep all medicine locked up and away from children. This is especially true of NAC.

    It is not approved for children.

    Store NAC away from heat and direct light. Do not store NAC in the bathroom, near the kitchen sink, or in other places that could be exposed to dampness.

    Heat and or moisture may cause the NAC to break down and not work effectively. As with all medicine, dispose of any products that are out of date or that are not needed.

    In view of the NAC contraindications, never share your NAC with others to help them. They may have one of the above conditions or medications and not have told you.

    Note that it has a very noxious odor that comes from the bottle when you open. This is normal.

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