Glioma

The Glioma Glutathione Connection. A Treatment?

Most people know what glioma is now because of the Senator Kennedy getting brain cancer. This is ironic as a dear friend was also recently diagnosed and had the surgery. She is a new mom and just started a new job.

Having met some of the Kennedy family (including their dog) and provided service for the Senators office in the past makes this an even more heart tugging subject.

First we will look at the basics and then the bad and good news.

Most importantly, there is some hopeful information.

Glioma Basics

Gliomas are perhaps one of the most interesting types of cancer. They are classified in a number of ways including type, grade and location.

They are further named by the type of cell they most resemble.

  • Ependymomas
  • Astrocytomas
  • Oligodendrogliomas
  • Oligoastrocytomas (mixed variety)

    They are classified further as Low Grade or High Grade. Low has the better prognosis.There is a WHO 1-4 system with 1 being the least aggressive.

    Symptoms

    The symptoms are dependent on the part of the nervous system affected.

    One in the brain can include headaches, nausea and vomiting, seizures, and cranial nerve disorders resulting from increased intracranial pressure.

    One in the optic nerve result in visual loss.

    In the spinal cord can cause pain, weakness, or numbness in the extremities.

    Although they are not thought to metastasize in the blood, they can spread in the cerebrospinal fluid to the spinal cord.

    Prognosis

    Current thinking is that they cannot be cured. The prognosis for patients with high-grade gliomas is generally poor. Age further reduces positive outcomes.

    Therapy

    Treatment is dependent on the type, location, and grade.

    The usual approach is surgery, chemotherapy, and radiation treatment.

    There are experimental therapies being researched.

    Bad News First

    My doctors have said that the potential is for a return in 6 months or 6 years or longer.They just don’t know.

    Some literature suggest survival of the worst kind is 12 months with the longest survival at 3 years.

    OK, where is the good news you ask?

    There is some good news. This is not to get false hopes. However, it is some interesting science.

    Even though this is a scientific paper, it says what many other studies also say.

    Signaling pathways involved in antioxidant control of glioma cell proliferation.

    Since this was hard to read (even for me) notice the highlighted sections. Remember this is only one of many studies that show this effect.

    Free Radic Biol Med. 2007 Jun 1;42(11):1715-22. Epub 2007 Mar 12.

    Signaling pathways involved in antioxidant control of glioma cell proliferation. Martín V, Herrera F, García-Santos G, Antolín I, Rodriguez-Blanco J, Rodriguez C.

    Departamento de Morfología y Biología Celular, Facultad de Medicina de la Universidad de Oviedo, c/Julian Clavería, 33006 Oviedo, Spain.

    Tumor cells are able to survive and proliferate despite the higher-than-average level of reactive oxygen species (ROS) they exhibit. This is generally taken as a clue as to the implications of ROS in cell proliferation. In fact many mitogenic intracellular signaling pathways could be redox regulated... In the present work we use N-acetylcysteine (NAC)...to study the implications of cellular redox state on rat C6 glioma cell proliferation. NAC is shown to decrease glioma cell proliferation, inducing a cell cycle arrest..... A rapid, and glutathione-independent, decrease in intracellular oxidants was observed as well.

    My thoughts here....the glutathione is decreased because it is throwing its self on the cancer like a marine on a grenade to save the cells around it.

    NAC also lowers Akt activity, extracellular signal-regulated kinase 1/2, and the redox-sensitive transcription factor NF-kappaB, all of which are ROS related and seem to be in close connection with cell proliferation. NAC effects apparently relate to protein kinase C (PKC) activity because 100 nM TPA-a PKC activator-induces a partial blockage of the NAC antiproliferative effect. Bringing our results together, it seems that intracellular reduction of oxidants in C6 glioma cells can induce inhibition of cell proliferation by modulating RTK-related intracellular signaling pathways

    PMID: 17462539

    There is a problem to note. NAC is contraindicated (should not be taken) due to interaction with some other medications unless fist consulting with both a Physician and Pharmacist. Why both? This is still cutting edge and the frontiers of knowledge.

    Some preparations actually say not to use NAC when on chemo or radiation treatment.

    The Great News

    There is a natural form of what NAC is chemically. This natural form is found in food. More specifically, milk. When you take this you will boost your bodies glutathione (GSH).

    When a baby gets this substance from its mothers breast milk, it has a 500% reduced risk of getting cancer.

    You and I can get it from cows milk.

    However, it has to be specially handled. It cannot be pasteurized the way most milk is or it will be rendered bio-inactive.

    The company that produces it even holds patents for and it is used by doctors to reduce the side effects of chemo therapy and radiation treatment. More importantly, it enhances the effect of those treatments. You will find it listed in the Physicians Desk Reference.

    It is an approved medical treatment for cancer. More importantly, it could be a glioma treatment?

    This is complimentary medicine at its best.

    If you are interested in getting it, please Call Me at Home call me. Yes, please call me at my home. If I am not there, it will forward to me or my wife.

    There are a few things you will need to know about it. Since many insurances do not cover it, we want to explain how to get it at the lowest price.

    Also, there are some dietary things to be concerned about. NO High Protein Diet for the same meal your taking this with.

    It has to be reconstituted. Since it is fragile, you have to shake it by hand. It is just this kind of stuff we would want you to know.

    Otherwise, you can buy it on line when ever you would like to.

    Click Here to Get my Number. If you like, you can Skype me too.

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